Sulfasalazine Baðlý Akciðer Hastalýðý: Olgu Sunumu

Ýlaca baðlý akciðer hastalýðýnýn ayýrýcý tanýsý zordur. Klinik, histolojik bulgularýn özgül olmamasý ve altta yatan hastalýðýn varlýðý ilaca baðlý akciðer hastalýðýnýn tanýsýnda zorluk yaratýr. Romatoid artrit tanýsý alan ve üç aydýr sulfasalazin kullanan 33 yaþýnda erkek hasta öksürük, nefes darlýðý ve kilo kaybý þikâyeti ile baþvurdu. Fizik muayenesinde romatoid artritin eklem tutulumu dýþýnda patolojiye rastlanmayan hastanýn toraks BT’sinde bilateral üst loblarda non homojen konsolidasyon alanlarý saptandý. Olguda mevcut klinik ve radyolojik bulgular sonucunda sulfasalazine baðlý akciðer hastalýðý düþünüldü. Sulfasalazin tedavisi kesildi ve klinik ve radyolojik düzelme görüldü. Sulfasalazine baðlý akciðer hastalýðý nadir görülmesi nedeni ile literatür bilgileri eþliðinde sunmayý amaçladýk.

Sulfasalazine-Induced Lung Disease: A Case Report

The differential diagnosis of drug-induced lung disease is difficult. Due to non-specific clinical and histological findings and the presence of underlying disease, the diagnosis of drug induced pulmonary disease is difficult. A 33-year-old man with a diagnosis of rheumatoid arthritis who had been treated with sulfasalazine for three months was admitted due to coughing, dyspnea, and weight loss. There were no pathological findings in the physical examination. Non-homogeneous infiltrates in the bilateral upper lobes were seen on the thorax CT. With these clinical and radiological findings in the patient, sulfasalazine-induced lung disease was considered. After sulfasalazine treatment was terminated, the patient's clinical and radiological findings improved. Because sul-fasalazine-induced lung disease is rarely observed, we aimed to present this case with literature reviews.