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Fluorourasil, Leucoverin ve Oxaliplatin Tedavisine Sekonder Akcier Toksistesi: Olgu Sunumu [Respir Case Rep]
Respir Case Rep. 2019; 8(1): 26-30 | DOI: 10.5505/respircase.2019.43433

Fluorourasil, Leucoverin ve Oxaliplatin Tedavisine Sekonder Akcier Toksistesi: Olgu Sunumu

Fatma Tokgz Akyl1, Mustafa Akyil2, Erdem en3, Meltem Aca4, Tlin Sevim4
1anakkale Devlet Hastanesi, Gs Hastalklar
2anakkale Devlet Hastanesi, Gs Cerrahisi
3anakkale Devlet Hastanesi, Onkoloji
4Sureyyapaa Gs Hastalklar Ve Gs Cerrahisi Eitim Ve Aratrma Hastanesi, Gs Hastalklar

Gnmzde, FOLFOX (5-fluorourasil, leucoverin ve oxaliplatin) ileri evre veya metastatik
gastrointestinal sistem tmrlerinde ilk srada kullanlan kemoteraptik rejimdir. Bu rejimin
hematolojik, gastrointestinal ve sensrinral sistem ile ilgili yan etkileri bilinmesine karn pulmoner
toksisitesi snrl sayda olgu bildirimleri dzeyindedir. Hzla ilerleyerek mortal seyredebileceinden
akcier toksisitesinin erken farkndal ve tedavisi nemlidir. Bu yazda, metastatik zofagus kanseri
nedeniyle kullanlan FOLFOX tedavisine sekonder gelien interstisyel akcier hastal olgusu nadir
olmas nedeniyle sunulmutur.

Anahtar Kelimeler: ila toksisitesi, interstisyel akcier hastal, oxaliplatin

Pulmonary Toxicity Secondary to Fluorouracil, Leucoverin and Oxaliplatin Treatment: A Case Report

Fatma Tokgz Akyl1, Mustafa Akyil2, Erdem en3, Meltem Aca4, Tlin Sevim4
1Canakkale State Hospital, Pulmonology
2Canakkale State Hospital, Thoracic Surgery
3Canakkale State Hospital, Oncology
4Sureyyapasa Chest Diseases And Thoracic Surgery Training And Research Hospital, Pulmonology

To date, 5-fluorourasil, leucovorin, and oxaliplatin (FOLFOX) continues to be used as a first-line treatment for advanced or metastatic gastrointestinal system tumors. Though associated hematological, gastrointestinal, and neurosensory toxicities are widely known, pulmonary toxicity has solely been described in case reports. Early diagnosis and treatment is extremely important, since the toxicity may lead to rapid deterioration and mortality. Presently described is the case of a female patient with interstitial lung disease secondary to undergoing a FOLFOX regimen for metastatic esophagus cancer.

Keywords: drug toxicity, interstitial lung disease, oxaliplatin

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Fatma Tokgz Akyl, Mustafa Akyil, Erdem en, Meltem Aca, Tlin Sevim. Pulmonary Toxicity Secondary to Fluorouracil, Leucoverin and Oxaliplatin Treatment: A Case Report. Respir Case Rep. 2019; 8(1): 26-30

Sorumlu Yazar: Fatma Tokgz Akyl, Trkiye
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