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Laparoscopic Endoscopic Surgical Science Metotreksata Bal Gelien Pulmoner Toksisite [Respir Case Rep]
Respir Case Rep. 2016; 5(3): 169-173 | DOI: 10.5505/respircase.2016.66487

Metotreksata Bal Gelien Pulmoner Toksisite

Selim Erkan Akdemir1, Pnar elik1, Timur Prldar2
1Celal Bayar niversitesi Tp Fakltesi, Gs Hastalklar Anabilim Dal, Manisa, Trkiye
2Celal Bayar niversitesi Tp Fakltesi, Romatoloji Bilim Dal, Manisa, Trkiye

Folat antagonisti olan metotreksat, inflamatuvar ve neoplastik hastalklarda kullanlr. Metotreksat kullanmna bal pulmoner toksisite nadirdir. Romatoid artrit nedeniyle 3 ay nce haftada bir 10 mg intramuskuler metotreksat ve 4 mg prednizolon balanan 67 yanda kadn hastada, nefes darl, ksrk, ate ve az iinde yara yaknmalar ortaya kmas, toraks bilgisayarl tomografide her iki akcierde st loblarda periferik yerleimli ve alt loblarda alveolar dk dansitede opasiteler ve konsolide alanlarn grlmesi zerine olas dispne nedenleri dlanm, klinik ve radyolojik olarak metotreksata bal pulmoner toksisite dnlm ve kortikosteroid tedavisi ile belirgin dzelme salanmtr. Tan ve tedavide gecikme lmcl sonulara yol aabilecei iin metotreksat kullanmna bal pulmoner toksisite geliebilecei akla getirilmelidir.

Anahtar Kelimeler: akcier, metotreksat, toksisite

Methotrexate-related Pulmonary Toxicity

Selim Erkan Akdemir1, Pnar elik1, Timur Prldar2
1Celal Bayar University School Of Medicine, Department Of Chest Diseases, Manisa, Turkey
2Celal Bayar University School Of Medicine, Department Of Rheumatology, Manisa, Turkey

Methotrexate (folate-antagonist) is used in the treatment of several inflammatory and neoplastic diseases. However pulmonary toxicity due to methotrexate is uncommon. Herein, we present a 67-year-old woman with rheumatoid arthritis who was treated with methotrexate 10 mg intramuscular weekly and oral methylprednisolone 4mg daily. She was admitted with dyspnea, cough, fever, and oral ulcers. Thoracic computed tomography revealed bilateral alveolar low intensity areas and consolidation in peripheral region of upper and lower lobes. Other possible causes of dyspnea were excluded. Based on the clinical and radiographic findings, the patient was diagnosed with methotrexate-related pulmonary toxicity. Her overall status improved dramatically with corticosteroid therapy. The clinician should keep in mind the possibility of methotrexate-related pulmonary toxicity in cases, as in our case, since delay in diagnosis and treatment can be fatal.

Keywords: lung, metotrexate, toxicity

Olgunun Grnt Kesitleri




Selim Erkan Akdemir, Pnar elik, Timur Prldar. Methotrexate-related Pulmonary Toxicity. Respir Case Rep. 2016; 5(3): 169-173

Sorumlu Yazar: Selim Erkan Akdemir, Trkiye
Makale Dili: Trke
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