Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Keratosis lichenoides chronica (KLC) is a rare and chronic skin disease characterized by erythema, keratotic and lichenoid papules are distributed symmetrically. The histological examination of KLC reveals lichenoid dermatitis with hyper and parakeratosis. Although the etiology and pathogenesis of KLC are unknown, it is suggested that KLC is a variant of lichen planus or lichenoid drug eruptions. We present a case of generalized KLC that occurred during antituberculosis therapy including isoniazid, rifampicin, ethambutol, and pyrazinamide and dramatically improved after cessation of therapy. We report this generalized KLC case in order to draw attention to the side effects that can be seen during tuberculosis treatment.

Tüberküloz Tedavisi Sýrasýnda Geliþen Jeneralize Keratozis Likenozis Kronika Olgusu

Keratozis Likenozis Kronika (KLK), simetrik daðýlým gösteren, eritemli, likenoid, keratotik papüllerle karakterize, nadir görülen kronik bir dermatozdur. Histopatolojik incelemede hiperkeratoz ve parakeratozun eþlik ettiði likenoid dermatit bulgusu görülür. Etyolojisi tam olarak bilinmemekle birlikte liken planus veya likenoid ilaç reaksiyonlarýnýn bir varyantý olduðu düþünülür. Tedavinin kesilmesiyle dramatik bir düzelme gösteren, isoniyazid, rifampisin, etambutol ve pirazinamidli antitüberküloz tedavi sýrasýnda oluþan Jeneralize KLK olgusunu, tüberküloz tedavisi sýrasýnda görülebilecek yan etkilere dikkat çekmek amacýyla sunuyoruz.