Respir Case Rep. 2016; 5(1): 10-14 | DOI: 10.5505/respircase.2016.32559

A Patient with Organizing Pneumonia Development During the Use of Capecitabine Maintenance Treatment for Gastric Cancer

Gökmen Aktaþ¹, Tülay Kuþ¹, Mehmet Emin Kalender¹, Kemal Bakýr², Celaletdin Camcý^1
1Department of Internal Medicine, Division of Oncology, Gaziantep University, Gaziantep, Turkey
²Department of Pathology, Gaziantep University, Gaziantep, Turkey

Organizing pneumonia (OP) is an inflammatory process of the bronchioles that can lead to destruction of small airways and surrounding lung tissue. Secondary OP, caused by anti-cancer drugs and radiotherapy, has previously been reported. In this study, we report the case of a 60-year-old female patient presented with OP, while using low dose capecitabine maintenance for stage IV gastric cancer under remission. After 18 months of routine follow-up with computed tomography (CT), a 9 mm subpleural nodule was presented at the right lung upper lobe posterior segment. Wedge resection was performed. Based on histopathologic examination, a diagnosis of OP was confirmed. In this instance, capecitabine was implicated as the likely cause of this drug-induced lung toxicity. This patient is the first case associated with development of OP during capecitabine monotherapy.

Keywords: Organizing pneumonia, capecitabine, solitary nodule, gastric cancer

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Mide Kanseri için Ýdame Kapesitabin Tedavisi Kullanan Bir Hastada Geliþen Organize Pnömoni Olgusu

Gökmen Aktaþ¹, Tülay Kuþ¹, Mehmet Emin Kalender¹, Kemal Bakýr², Celaletdin Camcý^1
1Gaziantep Üniversitesi, Ýç Hastalýklarý Anabilim Dalý, Týbbi Onkoloji Bilim Dalý, Gaziantep
²Gaziantep Üniversitesi, Patoloji Anabilim Dalý, Gaziantep

Organize pnömoni (OP) küçük havayollarý ve etrafýndaki dokularda hasara yol açabilen bronþiollerin inflamatuvar bir sürecidir. Antikanser ilaçlar ve radyoterapiye baðlý sekonder OP daha önce bildirilmiþtir. Bu makalede, remisyonda evre 4 mide kanseri nedeniyle idame düþük doz kapesitabin kullanýrken OP geliþen 60 yaþýnda bir kadýn hasta sunulmuþtur. On sekiz ay süresine kapesitabin tedavisi altýnda iken rutin bilgisayarlý tomografi tetkikinde sað akciðer üst lob posterior segmentte 9 mm subplevral nodül saptanmýþ ve kama rezeksiyon uygulanmýþtýr. Histopatolojik incelemede OP tanýsý koyulmuþtur. Bu durum ilaç iliþkili akciðer toksisitesi olarak düþünülmüþtür. Bu hasta uzun süreli kapesitabin monoterapisi altýnda OP geliþen literatürdeki ilk olgudur.

Anahtar Kelimeler: Organize pnömoni, kapesitabin, soliter nodül, gastrik kanser.

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