Respir Case Rep. 2022; 11(1): 44-49 | DOI: 10.5505/respircase.2022.80948

Rare Interstitial Pneumonia Due to the Use of Aripiprazol: A Case Report

Gülistan Alpagat, Ayþe Baccýoðlu, Sümeyra Alan Yalým, Merve Poyraz, Betül Dumanoðu, Ayþe Füsun Kalpaklýoðlu
Department of Immunology and Allergy Disease, Kýrýkkale University Faculty of Medicine, Kýrýkkale, Turkey

It is accepted that 2–3% of interstitial lung diseases (ILD) are due to drugs, and that 70% of drug-induced lung diseases are due to ILD. We present here the case of a 51-year-old female patient who had been taking aripiprazole for bipolar disorder for 3 years and had been undergoing asthma treatment for 2 years. ILD was considered based on the patient's clinic, a restrictive pattern in the pulmonary function test (PFT), a decreased carbon monoxide diffusion test, laboratory results, radiological findings and biopsy. The possible etiologies of infection, aspiration, heart failure, pet feeding status and exposure to hazardous respiratory substances were excluded. The suspected drug was discontinued and oral corticosteroid treatment was started. Lung toxicity can develop with drug treatments, and so drug history should be questioned in detail and discontinued immediately in case of any doubt. ILD is rare, and if the drug is not suspected and continued, the disease may become chronic and progress to respiratory failure. We present this case to increase awareness of the disease.

Keywords: Interstitial Lung Disease, aripiprazole, interstitial pneumonitis, steroid treatment

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Aripiprazol Kullanýmýna Baðlý Nadir Görülen Ýnterstisyel Pnömoni: Olgu Sunumu

Gülistan Alpagat, Ayþe Baccýoðlu, Sümeyra Alan Yalým, Merve Poyraz, Betül Dumanoðu, Ayþe Füsun Kalpaklýoðlu
Kýrýkkale Üniversitesi Týp Fakültesi, Ýmmunoloji ve Allerji Hastalýklarý, Kýrýkkale

Ýnterstisyel akciðer hastalýklarýnýn (IAH) %2-3'unun ilaçlara baðlý olduðu ve ilaca baðlý akciðer hastalýklarýnýn %70'inin IAH'dan olduðu kabul edilmektedir. Elli bir yaþýnda kadýn hasta 3 yýldýr bipolar bozukluk için aripiprazol kullanmakta ve 2 yýldýr astým tedavisi görmekteydi. Hastanýn kliniði, solunum fonksiyon testinde (SFT) restriktif patern olmasý, azalmýþ karbon monoksit difüzyon testi, laboratuvar sonuçlarý, radyolojik bulgularý ve biyopsi ile IAH düþünüldü. Olasý etiyolojiler: enfeksiyon, aspirasyon, kalp yetmezliði, evcil hayvan besleme durumu, tehlikeli solunum maddelerine maruziyet dýþlandý. Þüpheli ilaç kesilerek, oral kortikosteroid tedavisi baþlandý. Ýlaç tedavileri ile akciðer toksisitesi geliþebilir. Ýlaç öyküsü ayrýntýlý olarak sorgulanmalý ve þüphe durumunda derhal kesilmelidir. IAH nadir görülür; ilaçtan þüphelenilmez de devam edilirse hastalýk kronikleþebilir ve solunum yetmezliðine ilerleyebilir. Hastalýkla ilgili farkýndalýðý artýrmak için bu olguyu sunmaya amaçladýk.

Anahtar Kelimeler: Ýnterstisyel Akciðer Hastalýðý, aripiprazol, interstisyel pnömoni, steroid tedavi

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Image Slices of the Case

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