Respir Case Rep. 2012; 1(2): 26-28 | DOI: 10.5505/respircase.2012.02486

Carbamazepine-Induced Lymphocytic Interstitial Pneumonitis

Ebru Damadoðlu¹, Cüneyt Saltürk¹, Ebru Sulu¹, Sevda Gökceer², Huriye Berk Takýr¹, Leyla Yaðcý Tuncer¹, Adnan Yýlmaz^1
1Süreyyapaþa Chest Diseases And Thoracic Surgery Training And Investigation Hospital, Departmant Of Pulmonology
²Göztepe Training And Invesitigation Hospital, Department Of Neurology

A twenty-seven-year-old male was admitted with cough, sputum production, dyspnea and weight loss. Postero-anterior chest x-ray showed bilateral, diffuse reticulonoduler infiltration. He had received tuberculosis treatment in the past and he had been on carbamazepine for 8 years for a seizure disorder. Three sputum smear examinations for acid-fast bacilli were negative. Pulmonary function tests revealed FVC of 2.35L (51 %), FEV1 of 2.12 L (54 %), FEV1/FVC of 90 %, DLCO of 39 % and DLCO/VA of 75 %. Fiberoptic bronchoscopy was normal. Transbronchial lung biopsy and bronchial washing were nondiagnostic. Right mini-thoracotomy and open lung biopsy were performed. Pathologic examination revealed diagnosis of lymphocytic interstitial pneumonitis. Carbamazepine was withdrawn after neurological consultation. The patient was clinically and functionally well two months later. Computed tomography of the thorax was completely normal. The patient was consideredto be compatible with carbamazepine-induced lymphocytic interstitial pneumonitis.

Keywords: carbamazepine, drug-induced, lymphocytic interstitial pneumonitis

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Karbamazepine Baðlý Lenfositik Ýnterstisyel Pnömoni

Ebru Damadoðlu¹, Cüneyt Saltürk¹, Ebru Sulu¹, Sevda Gökceer², Huriye Berk Takýr¹, Leyla Yaðcý Tuncer¹, Adnan Yýlmaz^1
1Süreyyapaþa Göðüs Hastalýklarý Ve Göðüs Cerrahisi Eðitim Ve Araþtýrma Hastanesi, Göðüs Hastalýklarý Kliniði
²Göztepe Eðitim Ve Araþtýrma Hastanesi, Nöroloji Kliniði

Yirmi yedi yaþýnda erkek hasta öksürük, balgam çýkarma, nefes darlýðý ve kilo kaybý yakýnmalarý ile baþvurdu. Arka-ön akciðer grafisi bilatera, yaygýn retikülonodüler infiltrasyon gösteriyordu. Hasta geçmiþte tüberküloz tanýsý ile tedavi almýþtý ve epilepsi nedeniyle 8 yýldýr karbamazepin kullanýyordu. Üç balgam örneði aside dirençli basil açýsýndan negatif idi. Solunum fonksiyon testinde FVC 2.35L (% 51), FEV1 2.12 L (% 54), FEV1/FVC % 90, DLCO % 39 ve DLCO/VA % 75 bulundu. Fiberoptik bronkoskopi normal idi. Transbronþiyal akciðer biyopsisi ve bronþiyal lavaj tanýsal deðildi. Sað mini torakotomi ile açýk akciðer biyopsisi yapýldý. Patolojik inceleme lenfositik interstisyel pnömoni olarak bildirildi. Nöroloji konsültasyonu sonrasý karbamazepin kesildi. Ýki ay sonra hasta klinik ve fonksiyonel olarak iyi idi. Toraks bilgisayarlý tomografi normal olarak deðerlendirildi. Hasta karbamazepine baðlý lenfositik interstisyel pnömoni olarak kabul edildi.

Anahtar Kelimeler: karbamazepin, ilaca baðlý, lenfositik interstisyel pnömoni

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