Respir Case Rep. 2015; 4(2): 92-95 | DOI: 10.5505/respircase.2015.02986

A Single Disease with Double Complications: Crohn’s Disease

Aysun Yakar¹, Fatih Yakar², Fatmanur Karaköse², Hatice K. Özçelik², Kübra Aþýk^2
1Ýstanbul Forensic Science Institute, Ministry of Justice, Ýstanbul Turkey
²Department of Pulmonary Medicine, Bezmialem Vakýf University Faculty of Medicine, Ýstanbul, Turkey

Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Extra intestinal manifestations of CD may involve almost every organ system. Thrombosis and thromboembolic events are more frequent than in the normal population; additionally, drugs that are used to control disease activity have many side effects. One of the main problems associated with these drugs are immunosuppression, which may lead to many infections and malignancy. We present a case of 62-year-old woman, who has been diagnosed with Crohn’s disease. She was admitted with complaints of shortness of breath. The patient was diagnosed with pulmonary thromboembolism through computerized tomography during admission. Low molecular weight heparin was initiated. During treatment, a skin discoloration was noticed in her lower extremities, and after thorough evaluation, the patient was diagnosed Kaposi's sarcoma by a skin biopsy. Although thromboembolic events are expected during inflammatory diseases, Kaposi's sarcoma development is not. We identified the immunosuppression as the most probable cause of Kaposi's sarcoma development.

Keywords: Crohn's disease, pulmonary thromboembolism, Kaposi's sarcoma, inflammatory bowel disease.

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Bir Hastalýk, Ýki komplikasyon: Crohn Hastalýðý

Aysun Yakar¹, Fatih Yakar², Fatmanur Karaköse², Hatice K. Özçelik², Kübra Aþýk^2
1Ýstanbul Adli Týp Kurumu, Adalet Bakanlýðý, Ýstanbul, Türkiye
²Bezmialem Vakýf Üniversitesi Týp Fakültesi, Göðüs Hastalýklarý Anabilim Dalý, Ýstanbul, Türkiye

Crohn hastalýðý, gastrointestinal sistemin kronik inflamatuar bir hastalýðýdýr. Hastalýk, gastrointestinal sistemin herhangi bir bölümünü tutabildiði gibi, neredeyse tüm organ sistemlerde de ekstraintestinal semptomlara neden olabilir. Crohn hastalarýnda tromboz ve tromboembolik olaylar normal popülasyondan daha sýk görülür. Ayný zamanda hastalýðýn aktivitesini kontrol altýna almak için kullanýlan ilaçlarýn da birçok yan etkisi vardýr. Bu ilaçlarla ilgili ana problemlerden biri immünsüpresyon olup enfeksiyonlara veya maligniteye yol açabilir. Crohn hastalýðý tanýsý olan 62 yaþýnda bayan hasta, nefes darlýðý þikâyetiyle baþvurdu. Çekilen toraks bilgisayarlý tomografisinde pulmoner tromboemboli saptandý ve düþük moleküler aðýrlýklý heparin tedavisi baþlandý. Tedavi süresinde alt ektremitede renk deðiþim farkedildi. Yapýlan cilt biyopsisinde Kaposi sarkomu tanýsý kondu. Her ne kadar inflamatuar hastalýklarda tromboembolik olaylar geliþebilse de, sarkom geliþmi beklenmemektedir. Diðer tüm nedenler dýþlandýktan sonra hastada en muhtemel neden hastalýðý kontrol etmek için kullanýlan immünsüpresif tedavi olarak belirlendi.

Anahtar Kelimeler: Crohn hastalýðý, Pulmoner tromboemboli, Kaposi sarkomu, Ýnflamatuar barsak hastalýðý.

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