Warfarin-Induced Hepatotoxicity: A Case Report

A 30-year-old male patient with no comorbidities was admitted to hospital after developing a pulmonary embolism and was started on warfarin treatment. His hepatic enzymes increased progressively. In the early period after warfarin, an elevated liver function test was observed on the 4th day. Hepatotoxicity was thought to have developed secondary to warfarin, and the enzymes decreased gradually after the warfarin treatment was discontinued. We present this case as evidence of the possible development of hepatotoxicity secondary to warfarin treatment, even in the early period of treatment, and to discuss the management and follow-up outcomes of such patients.

Warfarine Sekonder Geliþen Hepatotoksisite: Olgu Sunumu

Otuz yaþýnda, bilinen ek hastalýðý olmayan erkek hasta pulmoner emboli tanýsý ile kliniðimize yatýrýldý. Takibinde varfarin tedavisi baþlanan hastada tedavinin dördüncü gününde karaciðer fonksiyon testlerinde yükseklik izlendi. Diðer nedenler dýþlanarak varfarine sekonder hepatotoksisite tanýsý konulan hastanýn varfarin kesildikten sonra deðerlerinde kademeli düþüþ izlendi. Bu olgu sunumunun amacý, varfarin tedavisine sekonder görülen hepatotoksisitenin, tedavinin erken döneminde de geliþebileceðini hatýrlatmak, bu hastalarýn yönetimi ve takibinin tartýþýlmasýdýr.

Image Slices of the Case