Respir Case Rep. 2022; 11(3): 170-175 | DOI: 10.5505/respircase.2022.24650

A Rare Tumor of the Posterior Mediastinum: Well-Differentiated Liposarcoma

Gözde Kalbaran Kýsmet¹, Oguzhan Okutan¹, Seda Mazmanoðlu Atýlman², Ismail Yýlmaz^3
1Department of Chest Diseases, University of Health Sciences Türki-ye, Hamidiye Faculty of Medicine, Sultan 2. Abdülhamid Han Health Application and Research Center, Ýstanbul, Türkiye
²Department of Pathology, Haydarpaþa Numune Training and Re-search Hospital, Ýstanbul, Türkiye
³Department of Pathology, University of Health Sciences Türkiye, Hamidiye Faculty of Medicine, Sultan II. Abdülhamid Han Health Application and Research Center, Ýstanbul, Türkiye

Liposarcoma is one of the most common forms of soft tissue sarcoma in adults, and usually occurs in the lower extremities and retroperitoneum. It has several histological subtypes, including myxoid, well-differentiated, dedifferentiated and pleomorphic. Liposarcomas originating from the mediastinum are extremely rare, and usually grow slowly and remain asymptomatic, but may become symptomatic when they become large enough to press on the adjacent structures. Computed tomography and magnetic resonance imaging provide useful data for diagnosis, while tissue biopsy based on typical pathological features is required for a definitive diagnosis. Complete surgical resection is the first-line treatment option as it is resistant to chemoradiotherapy. Due to the high risk of recurrence, long-term follow-up should be continued. We present here the rare case of a 56-year-old female patient with primary mediastinal liposarcoma who presented with a complaint of cough.

Keywords: Atypical Lipomatous Tumor, CDK4, Well-Differentiated Liposarcoma, MDM2

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Posterior Mediastenin Nadir Bir Tümörü: Ýyi Diferansiye Liposarkom

Gözde Kalbaran Kýsmet¹, Oguzhan Okutan¹, Seda Mazmanoðlu Atýlman², Ismail Yýlmaz^3
1SBÜ Sultan 2. Abdülhamid Han SUAM, Göðüs Hastalýklarý Servisi, Ýstanbul
²Haydarpaþa Numune Eðitim ve Araþtýrma Hastanesi, Patoloji Servisi, Ýstanbul
³SBÜ Sultan 2. Abdülhamid Han SUAM, Patoloji Servisi, Ýstanbul

Liposarkom eriþkinlerde en sýk görülen yumuþak doku sarkomlarýndan biridir; genellikle alt ekstremitelerde ve retroperitonda ortaya çýkar. Miksoid, iyi diferansiye, farklýlaþmamýþ (dediferansiye) ve pleomorfik olmak üzere çeþitli histolojik alt tipleri vardýr. Mediastenden kaynaklanan liposarkomlar son derece nadirdir. Bu tümörler genellikle yavaþ büyürler ve asemptomatik kalýrlar ancak büyük boyuta ulaþýp komþu yapýlara basý yaptýðýnda semptomatik olabilirler. Bilgisayarlý tomografi ve manyetik rezonans görüntüleme taný için faydalý veriler saðlar. Kesin taný için doku biyopsisi gereklidir ve tanýsý tipik patolojik özelliklere dayanýr. Kemoradyoterapiye duyarlý olmadýðýndan tam cerrahi rezeksiyon birinci basamak tedavi seçeneðidir. Nüks oraný yüksek olduðundan uzun süreli takip yapýlmalýdýr. Bu yazýda öksürük þikayeti ile baþvuran primer mediastinal liposarkomlu 56 yaþýnda kadýn olgu nadir görülmesi sebebiyle sunuldu.

Anahtar Kelimeler: Atipik Lipomatöz Tümör, CDK4, Ýyi Diferansiye Liposarkom, MDM2

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Image Slices of the Case

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