Respir Case Rep. 2013; 2(3): 143-146 | DOI: 10.5505/respircase.2013.36349

Familial Mediterranean Fever is a rare cause of recurrent pleural effusion

Savas Ozsu, Neslihan Ozcelik, Yilmaz Bulbul
Department Of Pulmonary Medicine, Karadeniz Technical University, School Of Medicine, Trabzon,turkey

Pleural effusion is a common condition and considered as an important clinical problem. The exudates remain a challenge for clinicians and 5-25% of the patients remain undiagnosed despite thorough investigations. Familial Mediterranean Fever (FMF) is an auto-inflammatory disorder with genetic origin showing an autosomal recessive inheritance pattern generally seen in certain ethnic groups characterized by recurrent fever and systemic findings. Exudative pleuritis has been reported as the solitary manifestation of the first FMF attack, in < 10% of patients. This case study describes a 70-year-old man with recurrent episodes of exudative pleuritis associated with pleuritic pain. After treatment with colchicine, 1.5 mg/d eliminated FMF attacks.

Keywords: Mediterranean fever, isolated pleural effusion, genetic analysis

---

Tekrarlayan plevral efüzyonun nadir bir nedeni Ailevi Akdeniz Ateþi

Savas Ozsu, Neslihan Ozcelik, Yilmaz Bulbul
Karadeniz Teknik Üniversitesi, Týp Fakültesi, Göðüs Hastalýklarý AD., Trabzon

Plevral effüzyon sýk görülen önemli bir problem olarak karþýmýza çýkmaktadýr. Eksuda ayrýmý klinisyenler için sorun oluþturmakta ve bazý hastalarda ileri incelemelere raðmen %5-25 oranýnda taný konulamamaktadýr. Ailesel Akdeniz ateþi (AAA) tekrarlayan ateþ ve sistemik bulgularla karakterize, genellikle etnik gruplarda görülen otozomal resesif geçiþ gösteren otoinflamatuar genetik orjinli gösteren bir hastalýktýr. Pulmoner hemoraji, infarkt ve infiltrasyon FMF’in önemli pulmoner komplikasyonlardadýr. Ýlk AAA ataðýnýn tek baþýna plörezi olarak ortaya çýkma oraný < %10'dur. Bu yazýda tekrarlayan plevral effüzyonla baþvuran ve izole pulmoner tutulumu olan 70 yaþýnda FMF tanýsý konulan bir olgu sunulmuþtur.

Anahtar Kelimeler: ailevi akdeniz ateþi, plevral efüzyon, genetik analiz

---

CITE