Respir Case Rep. 2019; 8(1): 26-30 | DOI: 10.5505/respircase.2019.43433

Pulmonary Toxicity Secondary to Fluorouracil, Leucoverin and Oxaliplatin Treatment: A Case Report

Fatma Tokgöz Akyýl¹, Mustafa Akyil², Erdem Þen³, Meltem Aðca⁴, Tülin Sevim^4
1Canakkale State Hospital, Pulmonology
²Canakkale State Hospital, Thoracic Surgery
³Canakkale State Hospital, Oncology
⁴Sureyyapasa Chest Diseases And Thoracic Surgery Training And Research Hospital, Pulmonology

To date, 5-fluorourasil, leucovorin, and oxaliplatin (FOLFOX) continues to be used as a first-line treatment for advanced or metastatic gastrointestinal system tumors. Though associated hematological, gastrointestinal, and neurosensory toxicities are widely known, pulmonary toxicity has solely been described in case reports. Early diagnosis and treatment is extremely important, since the toxicity may lead to rapid deterioration and mortality. Presently described is the case of a female patient with interstitial lung disease secondary to undergoing a FOLFOX regimen for metastatic esophagus cancer.

Keywords: drug toxicity, interstitial lung disease, oxaliplatin

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Fluorourasil, Leucoverin ve Oxaliplatin Tedavisine Sekonder Akciðer Toksistesi: Olgu Sunumu

Fatma Tokgöz Akyýl¹, Mustafa Akyil², Erdem Þen³, Meltem Aðca⁴, Tülin Sevim^4
1Çanakkale Devlet Hastanesi, Göðüs Hastalýklarý
²Çanakkale Devlet Hastanesi, Göðüs Cerrahisi
³Çanakkale Devlet Hastanesi, Onkoloji
⁴Sureyyapaþa Göðüs Hastalýklarý Ve Göðüs Cerrahisi Eðitim Ve Araþtýrma Hastanesi, Göðüs Hastalýklarý

Günümüzde, FOLFOX (5-fluorourasil, leucoverin ve oxaliplatin) ileri evre veya metastatik
gastrointestinal sistem tümörlerinde ilk sýrada kullanýlan kemoterapötik rejimdir. Bu rejimin
hematolojik, gastrointestinal ve sensörinöral sistem ile ilgili yan etkileri bilinmesine karþýn pulmoner
toksisitesi sýnýrlý sayýda olgu bildirimleri düzeyindedir. Hýzla ilerleyerek mortal seyredebileceðinden
akciðer toksisitesinin erken farkýndalýðý ve tedavisi önemlidir. Bu yazýda, metastatik özofagus kanseri
nedeniyle kullanýlan FOLFOX tedavisine sekonder geliþen interstisyel akciðer hastalýðý olgusu nadir
olmasý nedeniyle sunulmuþtur.

Anahtar Kelimeler: ilaç toksisitesi, interstisyel akciðer hastalýðý, oxaliplatin

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Image Slices of the Case

Tedavi Sonrasý

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