Respir Case Rep. 2018; 7(1): 9-12 | DOI: 10.5505/respircase.2018.82687

Malignant Pleural Mesothelioma and Central Nervous System Metastases: Report of Two Cases

Berna Akýncý Özyürek¹, Yurdanur Erdoðan¹, Meriç Ünver², Tuðçe Þahin Özdemirel¹, Funda Demirað³, Sadi Kaya^4
1Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, An-kara, Turkey
²Harakani State Hospital, Kars, Turkey
³Department of Pathology, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey
⁴Department of Thoracic Surgery, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey

At the time of diagnosis of malignant pleural mesothelioma (MPM), distant metastases are rare, but can occur through the hematogenous route or an adjacent route. Central nervous system (CNS) metastasis is rarely seen and the incidence is not known. Metastases occur more often in patients with relatively prolonged survival following aggressive treatment. Metastasis most often occurs in the cerebral cortex, cerebellum, intracranial meninges, or the spinal cord. CNS metastases can be seen in all histological types of MPM. Presently described are the cases of 2 patients diagnosed with malignant mesothelioma and in whom a rarely seen cranial metastasis was determined.

Keywords: Malignant pleural mesothelioma, Central nervous system metastasis, survey

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Malign Plevral Mezoltelyoma ve Santral Sinir Sistemi Metastazý: Ýki Olgu Sunumu

Berna Akýncý Özyürek¹, Yurdanur Erdoðan¹, Meriç Ünver², Tuðçe Þahin Özdemirel¹, Funda Demirað³, Sadi Kaya^4
1Atatürk Göðüs Hastalýklarý ve Göðüs Cerrahisi Eðitim Araþtýrma Hastanesi, Göðüs Hastalýklarý Kliniði, Ankara
²Harakani Devlet Hastanesi, Kars
³Atatürk Göðüs Hastalýklarý ve Göðüs Cerrahisi Eðitim Araþtýrma Hastanesi, Patoloji Bölümü, Ankara
⁴Atatürk Göðüs Hastalýklarý ve Göðüs Cerrahisi Eðitim Araþtýrma Hastanesi, Göðüs Cerrahisi, Ankara, Türkiye

Malign plevral mezotelyoma (MPM)’de taný esnasýnda uzak metastazlar nadiren görülür. Uzak metastaz hematojen yolla ya da komþuluk yoluyla olur. Santral sinir sistemi metastazý nadir görülür. Özellikle agresif tedaviler sonrasýnda nispeten surveyi uzayan hastalarda metastazlara daha sýk rastlanýr. Metastazlar sýklýkla serebral korteks, serebellum, intrakranial meninksler ve spinal kordda görülür. MPM' nin bütün histopatolojik tiplerinde görülebilir. Nadir görülmesi nedeniyle kranial metastaz saptanan malign mezotelyoma tanýsý olan 2 olgumuzu sunmayý amaçladýk.

Anahtar Kelimeler: Malign plevral mezotelyoma, santral sinir sistemi, survey

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