Mide Kanseri i�in �dame Kapesitabin Tedavisi Kullanan Bir Hastada Geli�en Organize Pn�moni Olgusu

Akta�, G�kmen; Ku�, T�lay; Kalender, Mehmet Emin; Bak�r, Kemal; Camc�, Celaletdin

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Mide Kanseri i�in �dame Kapesitabin Tedavisi Kullanan Bir Hastada Geli�en Organize Pn�moni Olgusu [Respir Case Rep]

Respir Case Rep. 2016; 5(1): 10-14 | DOI: 10.5505/respircase.2016.32559

Mide Kanseri i�in �dame Kapesitabin Tedavisi Kullanan Bir Hastada Geli�en Organize Pn�moni Olgusu

G�kmen Akta�¹, T�lay Ku�¹, Mehmet Emin Kalender¹, Kemal Bak�r², Celaletdin Camc�¹
¹Gaziantep �niversitesi, �� Hastal�klar� Anabilim Dal�, T�bbi Onkoloji Bilim Dal�, Gaziantep
²Gaziantep �niversitesi, Patoloji Anabilim Dal�, Gaziantep

Organize pn�moni (OP) k��k havayollar� ve etraf�ndaki dokularda hasara yol a�abilen bron�iollerin inflamatuvar bir s�recidir. Antikanser ila�lar ve radyoterapiye ba�l� sekonder OP daha �nce bildirilmi�tir. Bu makalede, remisyonda evre 4 mide kanseri nedeniyle idame d��k doz kapesitabin kullan�rken OP geli�en 60 ya��nda bir kad�n hasta sunulmu�tur. On sekiz ay s�resine kapesitabin tedavisi alt�nda iken rutin bilgisayarl� tomografi tetkikinde sa� akci�er �st lob posterior segmentte 9 mm subplevral nod�l saptanm�� ve kama rezeksiyon uygulanm��t�r. Histopatolojik incelemede OP tan�s� koyulmu�tur. Bu durum ila� ili�kili akci�er toksisitesi olarak d��n�lm��t�r. Bu hasta uzun s�reli kapesitabin monoterapisi alt�nda OP geli�en literat�rdeki ilk olgudur.

Anahtar Kelimeler: Organize pn�moni, kapesitabin, soliter nod�l, gastrik kanser.

A Patient with Organizing Pneumonia Development During the Use of Capecitabine Maintenance Treatment for Gastric Cancer

G�kmen Akta�¹, T�lay Ku�¹, Mehmet Emin Kalender¹, Kemal Bak�r², Celaletdin Camc�¹
¹Department of Internal Medicine, Division of Oncology, Gaziantep University, Gaziantep, Turkey
²Department of Pathology, Gaziantep University, Gaziantep, Turkey

Organizing pneumonia (OP) is an inflammatory process of the bronchioles that can lead to destruction of small airways and surrounding lung tissue. Secondary OP, caused by anti-cancer drugs and radiotherapy, has previously been reported. In this study, we report the case of a 60-year-old female patient presented with OP, while using low dose capecitabine maintenance for stage IV gastric cancer under remission. After 18 months of routine follow-up with computed tomography (CT), a 9 mm subpleural nodule was presented at the right lung upper lobe posterior segment. Wedge resection was performed. Based on histopathologic examination, a diagnosis of OP was confirmed. In this instance, capecitabine was implicated as the likely cause of this drug-induced lung toxicity. This patient is the first case associated with development of OP during capecitabine monotherapy.

Keywords: Organizing pneumonia, capecitabine, solitary nodule, gastric cancer

Sorumlu Yazar: G�kmen Akta�, T�rkiye
Makale Dili: �ngilizce

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