Respir Case Rep. 2014; 3(2): 114-117 | DOI: 10.5505/respircase.2014.58569

Tüberküloz Tedavisi Sýrasýnda Geliþen Jeneralize Keratozis Likenozis Kronika Olgusu

Ýlkin Zindancý¹, Hacer Kuzu Okur², Ebru Zemheri³, Burce Can¹, Zafer Turkoglu¹, Mukaddes Kavala¹, Ozge Akbulak¹, Filiz Topaloglu^1
1Medeniyet Üniversitesi, Göztepe Eðitim Hastanesi Dermatoloji Kliniði, Göztepe, Istanbul, Türkiye
²Fatih Sultan Mehmet Eðitim Ve Araþtýrma Hastanesi, Göðüs Hastalýklarý Kliniði, Kozyataðý, Ýstanbul, Türkiye
³Medeniyet Üniversitesi, Göztepe Eðitim Hastanesi Patoloji Kliniði, Göztepe, Istanbul, Türkiye

Keratozis Likenozis Kronika (KLK), simetrik daðýlým gösteren, eritemli, likenoid, keratotik papüllerle karakterize, nadir görülen kronik bir dermatozdur. Histopatolojik incelemede hiperkeratoz ve parakeratozun eþlik ettiði likenoid dermatit bulgusu görülür. Etyolojisi tam olarak bilinmemekle birlikte liken planus veya likenoid ilaç reaksiyonlarýnýn bir varyantý olduðu düþünülür. Tedavinin kesilmesiyle dramatik bir düzelme gösteren, isoniyazid, rifampisin, etambutol ve pirazinamidli antitüberküloz tedavi sýrasýnda oluþan Jeneralize KLK olgusunu, tüberküloz tedavisi sýrasýnda görülebilecek yan etkilere dikkat çekmek amacýyla sunuyoruz.

Anahtar Kelimeler: Tüberküloz tedavisi, pirazinamid, keratozis likenozis kronika, Nekam’s hastalýðý

---

Generalized Keratosis Lichenoides Chronica Induced By Antituberculosis Therapy: A Case Report

Ýlkin Zindancý¹, Hacer Kuzu Okur², Ebru Zemheri³, Burce Can¹, Zafer Turkoglu¹, Mukaddes Kavala¹, Ozge Akbulak¹, Filiz Topaloglu^1
1Medeniyet University, Sb Goztepe Training And Research Hospital, Department Of Dermatology, Istanbul; Turkey
²Fatih Sultan Mehmet Training And Research Hospital, Department Of Chest Diseases, Istanbul
³Medeniyet University, Sb Goztepe Training And Research Hospital, Department Of Pathology, Istanbul, Turkey

Keratosis lichenoides chronica (KLC) is a rare and chronic skin disease characterized by erythema, keratotic and lichenoid papules are distributed symmetrically. The histological examination of KLC reveals lichenoid dermatitis with hyper and parakeratosis. Although the etiology and pathogenesis of KLC are unknown, it is suggested that KLC is a variant of lichen planus or lichenoid drug eruptions. We present a case of generalized KLC that occurred during antituberculosis therapy including isoniazid, rifampicin, ethambutol, and pyrazinamide and dramatically improved after cessation of therapy. We report this generalized KLC case in order to draw attention to the side effects that can be seen during tuberculosis treatment.

Keywords: Tuberculosis treatment, pyrazinamide, keratosis lichenoides chronica, Nekam’s disease

---

ATIF KOPYALA