�NTERAKT�F OLGU SUNUMU:  Akci�er Adenokarsinomunun Kolona Beklenmeyen Metastaz�

Ogan, Nalan; Bekir, S�meyye Alparslan; �oban, Mehmet; Kaplan, Tevfik; Atao�lu, �m�r; G�lhan, Meral

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�NTERAKT�F OLGU SUNUMU: Akci�er Adenokarsinomunun Kolona Beklenmeyen Metastaz� [Respir Case Rep]

Respir Case Rep. 2015; 4(3): 147-150 | DOI: 10.5505/respircase.2015.50479

�NTERAKT�F OLGU SUNUMU: Akci�er Adenokarsinomunun Kolona Beklenmeyen Metastaz�

Nalan Ogan¹, S�meyye Alparslan Bekir¹, Mehmet �oban², Tevfik Kaplan³, �m�r Atao�lu⁴, Meral G�lhan¹
¹Ufuk �niversitesi T�p Fak�ltesi, G��s Hastal�klar� Anabilim Dal�, Ankara
²Ufuk �niversitesi T�p Fak�ltesi, Gastroenteroloji Bilim Dal�, Ankara
³Ufuk �niversitesi T�p Fak�ltesi, G��s Cerrahisi Anabilim Dal�, Ankara
⁴Mikropat Patoloji Laboratuvar�, Ankara

Akci�er kanseri, d�nyada kanser �l�mleri aras�nda ilk s�ralardad�r ve tan� an�nda hastalar�n yakla��k %50� sinde uzak metastaz saptan�r. Primeri akci�er kaynakl� semptomatik kolon metastaz� ise �ok nadirdir. �mm�nohistokimyasal boyama akci�er kanserinin ay�r�c� tan�s�nda de�erlidir. Akci�er adenokarsinomlar�nda genellikle sitokeratin-7(CK-7) pozitif, sitokeratin-20 (CK-20) negatif, bunun tam tersi kolorektal adenokanserlerin akci�er metastaz�nda ise CK-7 negatif, CK-20 pozitiftir. Gastrointestinal tutulumu olan akci�er karsinomunun prognozu k�t�d�r ve ortalama 4-8 haftal�k sa�kal�m s�resi mevcuttur. Akci�er kanserli bir hastada kolonda t�m�r saptand��nda bunun ikinci primer t�m�r olma olas�l�� durumunun metastazdan ay�r�m� hastalar�n tedavi yakla��m�nda �nem ta��r.

Anahtar Kelimeler: Akci�er kanseri, kolon metastaz�, imm�nohistokimyasal boyama.

INTERACTIVE CASE REPORT: Unexpected Colon metastasis of Lung Adenocarcinoma

Nalan Ogan¹, S�meyye Alparslan Bekir¹, Mehmet �oban², Tevfik Kaplan³, �m�r Atao�lu⁴, Meral G�lhan¹
¹Department of Chest Diseases, Ufuk University Faculty of Medicine, Ankara, Turkey
²Department of Gastroenterology, Ufuk University Faculty of Medicine, Ankara, Turkey
³Department of Thoracic Surgery, Ufuk University Faculty of Medicine, Ankara, Turke
⁴Mikropat Pathology Laboratory, Ankara, Turkey

Lung cancer is one of the most common causes of cancer deaths worldwide and at diagnosis approximately 50% of the patients have distant metastases. However, symptomatic colon metastasis of primary lung adenocarcinoma is very rare. Immunohistochemical staining is valuable in the differential diagnosis of lung cancer. Lung adenocarcinomas are generally positive for cytokeratin-7 (CK-7) staining and negative for cytokeratin-20 (CK-20) staining. On the other hand, lung metastases of colorectal adenocarcinomas are generally negative for CK-7 staining and positive for CK-20 staining. The prognosis of lung cancer patients with gastrointestinal involvement is poor and the average survival time is from four to eight weeks. The differential diagnosis of colorectal tumors as primary or metastasis, in patients with lung cancer, is important in terms of treatment strategy.

Keywords: Lung cancer, colon metastases, immunohistochemical staining.

Olgunun G�r�nt� Kesitleri

Sorumlu Yazar: Nalan Ogan, T�rkiye
Makale Dili: T�rk�e

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