Respir Case Rep. 2016; 5(2): 112-116 | DOI: 10.5505/respircase.2016.32448

Ýlaca Baðlý Akciðer Hastalýðý: Ýki Olgu Sunumu

Ýlim Irmak, Dilek Ernam, Ülkü Aka Aktürk, Feyyaz Kabadayý, Hasan Özgen, Makbule Özlem Akbay, Erhan Oður, Ali Metin Görgüner
Süreyyapaþa Göðüs Hastalýklarý ve Göðüs Cerrahisi Eðitim Araþtýrma Hastanesi, Göðüs Hastalýklarý Kliniði, Ýstanbul

Klinik, radyolojik ve histolojik bulgularýnýn özgül olmamasý ve nadir görülmesi nedeniyle ilaca baðlý akciðer hastalýklarýnýn ayrýcý tanýsýný yapmak güçtür. Ülseratif kolit tanýsý ile 10 yýldýr sulfasalazin kullanan 80 yaþýnda ve kronik piyelonefrit nedeniyle bir yýldýr nitrofurantoin kullanýmý olan 70 yaþýnda olmak üzere iki bayan hasta nefes darlýðý þikâyeti ile merkezimize baþvurdu. Altta yatan hastalýklar dýþýn-da anormal muayene bulgusu saptanmayan hastalarýn toraks bilgisayarlý tomografilerinde bilateral non homojen konsolidasyon ve interstisyel tutulum alanlarý mevcuttu. Klinik, radyolojik bulgular ve uygulanan giriþimsel tetkikler sonucu olgularda ilaca baðlý akciðer hastalýðý düþünüldü. Ýlacýn kesilmesi ile hastalarda klinik ve radyolojik düzelme görüldü. Nitrofurantoin ve sulfasalazine baðlý geli-þen akciðer hastalýðýnýn nadir görülmesi nedeniyle bu olgularý sunduk.

Anahtar Kelimeler: Ýlaç, Akciðer Hastalýðý, sulfasalazin, nitrofurantoin

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Drug-Induced Lung Disease: Report of Two Cases

Ýlim Irmak, Dilek Ernam, Ülkü Aka Aktürk, Feyyaz Kabadayý, Hasan Özgen, Makbule Özlem Akbay, Erhan Oður, Ali Metin Görgüner
Department of Chest Diseases, Süreyyapaþa Chest Dis-eases and Chest Surgery Training and Research Hospital, Ýstanbul, Turkey

As a considerable number of drugs has the potential of pulmonary toxicity, the diagnosis of drug-induced lung disease is an important challenge. Herein, we present two female cases. The first case was an 80-year-old woman who was under sulfasalazine treatment for ulcerative colitis and the other case was a 70-year-old woman who was under nitrofurantoin treatment due to chronic pyelonephritis. Their physical examination findings were normal and both patients had non-homogenous consolidations with interstitial involvement on computed tomography. Based on the clinical and radiological findings in conjunction with the results of invasive procedures, drug-induced lung disease was suggested. Clinical and radiological improvement was achieved with the discontinuation of the drugs. We report these cases due to its rarity.

Keywords: Drug, Lung disease, sulfasalazine, nitrofurantoine

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ATIF KOPYALA