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Erken dnem gs duvar metastaz oluturan akcierin byk hcreli nroendokrin karsinomu [Respir Case Rep]
Respir Case Rep. 2016; 5(3): 204-208 | DOI: 10.5505/respircase.2016.43660

Erken dnem gs duvar metastaz oluturan akcierin byk hcreli nroendokrin karsinomu

Fazl Yank1, Yekta Altemur Karamustafaolu1, Adem Karata1, Ebru Tatekin2
1Trakya niversitesi Tp Fakltesi, Gs Cerrahisi Ana Bilim Dal, Edirne
2Trakya niversitesi Tp Fakltesi, Patoloji Ana Bilim Dal, Edirne

Akcierin byk hcreli nroendokrin karsinomlar (BHNK) yksek gradeli tmrlerdir ve kk hcreli akcier kanserine(KHAK) benzer klinik ve biyolojik zellikler tarlar. Erken dnem gs duvar metastaz oluturan akcierin bir BHNKli olguyu tartmay amaladk. Altm iki yanda erkek hastann toraks bilgisayarl tomografisinde (BT) sol akcier st lob anterior segmentte 1,5 cm solid kitle izlendi. Pozitron emisyon tomografisinde kitle malign karakterdeydi. Peroperatuvar frozen sonucu; kk hcreli d akcier kanseri (KHDAK) gelmesi zerine sol st lobektomi uyguland. Sonu gastrointestinal sistem kaynakl p(T1aN0M0) nroendokrin karsinom olarak raporland. Primer kaynaa ynelik yaplan oktreotid sintigrafisi, gastroskopi, kolonoskopi, batn-toraks BTde bir patoloji saptanmad. Olgunun 3. ay kontrolnde; gs duvarnda kitle tespit edildi ve alnan biyopsi BHNK metastaz olarak raporland. Olguya kemo-radyoterapi planland. Olgu tandan bir yl sonra kaybedildi. BHNKler hzl metastaz yapabilen, agresif seyirli, nks edebilen tmrler olduklar iin dier KHDAKlerinden ayrlmas nemlidir, bu hastalarda yakndan takibe ihtiya vardr.

Anahtar Kelimeler: Byk hcreli nroendokrin kanser, nroendokrin tmrler, akcier tmrleri.

Large cell neuroendocrine carcinoma of lung with early chest wall metastasis

Fazl Yank1, Yekta Altemur Karamustafaolu1, Adem Karata1, Ebru Tatekin2
1Department Of Thoracic Surgery, Trakya University Faculty Of Medicine,edirne,turkey
2Department Of Pathology, Trakya University Faculty Of Medicine,edirne,turkey

The large cell neuroendocrine carcinomas of the lung (LCNEC) are high-grade tumors and they have similar clinical and biological characteristics of non-small cell lung cancer (NSCLC). We discuss a patient with LCNEC of the lung which early metastasis to chest wall. Sixty-two-year-old male patient had a 1.5 cm solid mass in left upper lob on computered tomography (CT). The mass was reported by positron emission tomography as malignant. Left upper lobectomy was applied in the same period, when perioperatively frozen-section result was diagnosed NSLC. Histopathological examination was revealed a neuroendocrine carcinoma, which may originate from the gastrointestinal tract p(T1AN0M0). The octreotide scintigraphy, gastroscopy, colonoscopy, abdominal, and chest CT were performed for primary origin, but did not reveal any pathology. Chest wall mass was detected postoperative third months and biopsy result was reported as large cell neuroendocrine carcinoma. Then, chemoradiotherapy was planned. Patient died after one year from diagnosis. Accurate differentiation of LCNEC from other types of NSCLC is important, and there is a need for close follow-up in these patients for aggressive and metastatic nature and recurrent disease.

Keywords: Large cell neuroendocrine carcinoma, neuroendocrine tumor, lung tumors.

Olgunun Grnt Kesitleri




Fazl Yank, Yekta Altemur Karamustafaolu, Adem Karata, Ebru Tatekin. Large cell neuroendocrine carcinoma of lung with early chest wall metastasis. Respir Case Rep. 2016; 5(3): 204-208

Sorumlu Yazar: Fazl Yank, Trkiye
Makale Dili: Trke
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