Respir Case Rep. 2015; 4(1): 38-43 | DOI: 10.5505/respircase.2015.73644

ÝNTERAKTÝF OLGU SUNUMU: Ýki Olgu Nedeni ile Pnömoniyi Taklit Eden Wegener Granülomatozis

Ceyda Mahleç Anar, Erdem Yalçýnkaya, Dursun Tatar, Pýnar Çimen, Filiz Güldaval, Ýpek Ünsal, Özlem Edipoðlu, Derya Deniz, Hüseyin Halilçolar
Dr. Suat Seren Göðüs Hastalýklarý ve Cerrahisi Eðitim Araþtýrma Hastanesi, Göðüs Hastalýklarý Bölümü, Ýzmir

Wegener granülomatozu (WG), üst ve alt solunum yollarýnýn nekrotizan granülomatöz vaskülitine iliþkin klinik- patolojik belirtileri, glomerülonefrit ve küçük damar vasküliti ile karakterize multisistemik tutulum yapan bir hastalýktýr. Ateþ, eritrosit sedimantasyon hýz yüksekliði, halsizlik bulgularý ile baþvurup, progresif böbrek yetmezliði saptanan, geniþ spektrumlu antibiyotik tedavisine raðmen pulmoner lezyonlarda progresyon gözlenen 68 yaþýnda bayan hasta, böbrek biyopsisi sonrasýnda WG tanýsý almýþtýr. Ýkinci olgumuz ise; ilk semptomu iþitme kaybý olan 31 yaþýnda erkek hasta 2 aydýr tekrarlayan üst solunum yolu enfeksiyon ataklarý ve son 1 haftadýr devam eden ateþ, halsizlik yakýnmasý ile baþvurdu. c-ANCA pozitifliði saptanan her iki olguyu enfeksiyon kliniði ile baþvurmuþ olup daha sonra Wegener tanýsý almasý nedeniyle sunmayý uygun bulduk.

Anahtar Kelimeler: Wegener granülomatozis, c-ANCA, pnömoni, ateþ.

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INTERACTIVE CASE REPORT: Wegener's Granulomatosis Mimicking Pneumonia: Two Cases

Ceyda Mahleç Anar, Erdem Yalçýnkaya, Dursun Tatar, Pýnar Çimen, Filiz Güldaval, Ýpek Ünsal, Özlem Edipoðlu, Derya Deniz, Hüseyin Halilçolar
Clinic of Chest Diseases, Dr. Suat Seren Chest Diseases and Surgery Training Hospital, Ýzmir, Turkey

Wegener’s granulomatosis (WG) is a necrotizing granulomatous vasculitic disease that particularly involves the upper and lower respiratory tract and kidneys. A 68-year-old female patient was admitted to the hospital, a high erythrocyte sedimentation rate, fever, and progressive renal failure. Progression was observed in the patient's pulmonary infiltrations in spýte of wide- spectrum antibiotherapy. The renal biopsy revealed Wegener’s granulomatosis. The second case, whose the first symptom was hearing loss, was a 31-year-old male patient who was admitted to the hospital with recurrent episodes of upper respiratory tract infection for two months and with symptoms of fever, and malaise for one week. The WG case with multiple organ involvement in which c-ANCA was determined positive and responded to treatment is discussed in this case presentation

Keywords: Wegener’s granulomatosis, c-ANCA, pneumonia, fever.

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ATIF KOPYALA