e-ISSN 2147-2475
Cilt : 11 Say : 3 Yl : 2022

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PET-BT'de Yksek Dzeyde FDG Tutulumu Olan Mediastinal Lenfadenopatilerde Granlamatz Hastalklar Dnlmelidir [Respir Case Rep]
Respir Case Rep. 2017; 6(2): 90-95 | DOI: 10.5505/respircase.2017.98705

PET-BT'de Yksek Dzeyde FDG Tutulumu Olan Mediastinal Lenfadenopatilerde Granlamatz Hastalklar Dnlmelidir

Burin elik1, Muhammed Ali Ylmaz1, Mehmet Gkhan Pirzirenli1, Murathan ahin2
1Ondokuz Mays niversitesi Tp Fakltesi, Gs Cerrahisi Ad, Samsun, Trkiye
2Ondokuz Mays niversitesi Tp Fakltesi, Nkleer Tp Ad, Samsun, Trkiye

Granlomatz hastalklar lkemizde olduka sk grlmektedir. Tberkloz ve sarkoidoz bu hastalklar ierisinde en bata gelenlerdir. Tberkloz sklkla akcierleri tutmasna ramen baz olgularda mediastinal lenf tutulumu eklinde de ortaya kmaktadr. Sarkoidoz ise sklkla mediastinal ve hiler lenfadenopatiler eklinde karmza kmaktadr. Bu makalede PET-BT incelemelerinde mediastinal maligniteyi taklit eden, yksek dzeyde F-18 FDG tutulumu olan granlamatz lenfadenit olgularn sunmay amaladk. Kliniimize PET-BT grntlerinde patolojik FDG tutulumu olan mediastinal LAP nedeniyle hasta bavurdu. Hastalarn ikisinde ksrk ve nefes darl ikayeti, birisi meme kanseri, uterus kanseri ve tiroit kanserinden ameliyat edilmiti. ki olgunun videomediastinoskopik lenf nodu biyopsi sonucu kazeifiye granlomatz iltihabi olay olarak rapor edildi. Nefes darl nedeniyle tetkik edilen hastann PET-BT'de subkarinal lenf nodu ve sol interlober lenf nodlarnda patolojik FDG tutulumu izlendi. Bu olgunun videomediastinoskopik lenf nodu biyopsi sonucu non-kazeifiye granlomatz iltihabi olay olarak rapor edildi. lkemizde tberkloz ve sarkoidoz gibi granlamatz hastalklar yanl pozitif FDG PET nedenleri arasnda en sk grlenlerdir. Olgularmzdaki gibi yksek FDG tutulumu olanlarda maligniteyi ekarte edebilmek iin doku biyopsisi gereklidir.

Anahtar Kelimeler: granlomatz hastalk, lenfadenopati, mediasten, PET-BT

Granulomatous Diseases Should be Considered in Mediastinal Lymphadenopathies with High F-18 FDG Uptake on PET-CT Scans

Burin elik1, Muhammed Ali Ylmaz1, Mehmet Gkhan Pirzirenli1, Murathan ahin2
1Ondokuz Mayis University Medical School, Department Of Thoracic Surgery, Samsun, Turkey
2Ondokuz Mayis University Medical School, Department Of Nuclear Medicine, Samsun, Turkey

Granulomatous diseases are quite common in our country; tuberculosis (TB) and sarcoidosis are the most common. TB mostly involves the lungs; however, in some cases, it may involve the mediastinal lymph nodes. Sarcoidosis, on the other hand, often reveals itself as mediastinal or hilar lymphadenopathy (LAP). Presently described are cases of granulomatous lymphadenitis that mimicked mediastinal malignancy in positron emission tomography-computed tomography (PET-CT) scanning and had high fludeoxyglucose (FDG) uptake. Three patients whose PET-CT scans revealed pathological FDG uptake due to mediastinal LAP were admitted to our clinic. Two had cough and dyspnea, and third had operated breast cancer, uterine cancer, and thyroid cancer. Videomediastinoscopic biopsies of 2 patients were reported as caseating granulomatous inflammation. In patient who was examined for dyspnea, PET-CT revealed pathological FDG uptake in subcarinal lymph nodes and the left interlobar lymph nodes. Videomediastinoscopic lymph node biopsy of this patient was reported as non-caseating granulomatous inflammation. Granulomatous diseases, such as TB and sarcoidosis, are the most common cause of false-positive FDG PET scans in our country. In cases with high FDG uptake, tissue biopsy can exclude malignancy.

Keywords: granulomatous disease, lymphadenopathy, mediastinum, PET-CT

Burin elik, Muhammed Ali Ylmaz, Mehmet Gkhan Pirzirenli, Murathan ahin. Granulomatous Diseases Should be Considered in Mediastinal Lymphadenopathies with High F-18 FDG Uptake on PET-CT Scans. Respir Case Rep. 2017; 6(2): 90-95

Sorumlu Yazar: Burin elik, Trkiye
Makale Dili: Trke
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