Plevral s�v�n�n bir nedeni Ailevi Akdeniz Ate�i

U�ur Chouse�n, Efsun Gonca; Karaosman Iliaz, Sinem; Abal�, H�lya; �zt�rk, Sakine; �a�lar, Emel

Cilt : 5 Say� : 3 Y�l : 2025

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Plevral s�v�n�n bir nedeni Ailevi Akdeniz Ate�i [Respir Case Rep]

Respir Case Rep. 2016; 5(3): 184-187 | DOI: 10.5505/respircase.2016.26056

Plevral s�v�n�n bir nedeni Ailevi Akdeniz Ate�i

Efsun Gonca U�ur Chouse�n¹, Sinem Karaosman Iliaz², H�lya Abal�¹, Sakine �zt�rk¹, Emel �a�lar¹
¹Yedikule G��s Hastal�klar� Ve Cerrahisi E�itim Ve Ara�t�rma Hastanesi Istanbul
²Ko� �niversitesi T�p Fak�ltesi G��s Hastal�klar� Departman� Istanbul

K�rk bir ya��nda kad�n hasta tekrarlayan ate�, sol yan a�r�s�, nefes darl�� yak�nmalar�yla ba�vurdu. Arka-�n akci�er grafisinde solda plevral ef�zyon ile uyumlu g�r�n�m saptand�. Torasentez ile al�nan plevral s�v� �rnekleri eksuda �zelli�inde olup n�trofil hakimiyeti mevcutu.Hastaya pl�ropn�moni tan�s�yla antibiyoterapi uyguland� ve klinik ve k�smi radyolojik iyile�meyle taburcu edildi. �� hafta sonra ayn� �ikayetlerle tekrar klini�imize m�racaat etti. Hastaya Video Assisted Torakoskopi uyguland�. Biyopsi sonucu kronik non-spesifik pl�rit olarak geldi. Anamnez derinle�tirildi�inde iki �ocu�unda Ailevi Akdeniz Ate�i( AAA) oldu�u ve hastan�n M680I( G/C) heterojen ta��y�c�s� oldu�u ��renildi. Romatoloji b�l�m�yle kons�lte edilerek hastaya oral kol�isin 0,5 mg 2x1 ba�land�. Bu tedaviden sonra hastan�n klini�i d�zeldi, plevral s�v�s� geriledi. AAA tan�s� olan hastalar�n�n %95 'inde ana yak�nma abdominal a�r�d�r. Abdominal a�r� olmaks�z�n plevral a�r� nadirdir. Plevral s�v� daha da nadirdir. Plevral ef�zyonlar�n etiyolojisini ara�t�r�rken Akdeniz b�lgesinde yer alan �lkemizde, AAA�nin de plevral s�v� nedeni olabilece�ini akl�m�zda tutmam�z gerekmektedir.

Anahtar Kelimeler: G��s a�r�s�, plevral s�v�, Ailevi Akdeniz Ate�i

A cause of pleural effusion is Familial Mediterranean Fever

Efsun Gonca U�ur Chouse�n¹, Sinem Karaosman Iliaz², H�lya Abal�¹, Sakine �zt�rk¹, Emel �a�lar¹
¹Yedikule Chest Diseases And Thoracic Surgery Education And Research Hospital, Department Of Pulmonary Medicine
²Koc University Hospital, Department Of Pulmonary Medicine

Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent abdominal pain and fever episodes. Pleural pain and effusion can also be seen, but rarely in the absence of abdominal pain. FMF is treated with colchicine to control symptoms and to prevent amyloidosis and renal failure. A 41-year-old woman was admitted to our hospital due to recurrent fever, chest pain, and dyspnea. She had an exudative pleural effusion and responded to antibiotic therapy with partial radiographic resolution. She had recurrence of her symptoms three weeks after the completion of therapy. Pleural biopsy by video-assisted thoracoscopy revealed chronic non-specific pleuritis. The patient disclosed that two of her offspring had FMF. Gene analysis showed she was heterozygous carrier of M680I (G/C) mutation. Treatment with colchicine led to resolution of her symptoms and of the pleural effusion. Turkey has a high prevalence of FMF. Pulmonologists should consider FMF in the differential diagnosis of patients with recurrent pleural effusions

Keywords: Chest pain, pleural effusion, Familial Mediterranian Fever

Sorumlu Yazar: Efsun Gonca U�ur Chouse�n, T�rkiye
Makale Dili: T�rk�e

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