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Plevral Mezotelyomal Bir Hastada Bilateral Non-arteritik skemik Optik Nropati ve Minimal Deiiklik Hastal [Respir Case Rep]
Respir Case Rep. 2019; 8(1): 21-25 | DOI: 10.5505/respircase.2019.14471

Plevral Mezotelyomal Bir Hastada Bilateral Non-arteritik skemik Optik Nropati ve Minimal Deiiklik Hastal

Senyo Tagboto
Yarmouth Blge Hastanesi, Yarmouth, Kanada

Malign mezotelyoma tipik olarak yava ilerleyen dispne ve gs ars ile kendini gstermektedir. Toraks d semptomlar ve paraneoplastik tablolar ok nadirdir. Bu maliginite ile glomerler hastalk birliktelii literatrde nadiren bildirilmitir. Bu olgu sunumunda, 26 yl nce mesleksel asbest maruziyeti olan son bir aydr yava ilerleyen grme kayb, hafif kilo kayb ve ayaklarda dem yaknmalar olan 65 yanda erkek hasta sunulmutur. Gz hastalklar uzmanlar tarafndan non-arteritik iskemik optik nropati gelitii belirlendi. leri nefrolojik incelemelerde renal biyopsi ile dorulanan minimal deiiklik hastalna bal nefrotik sendrom olduu gsterildi. Steroid tedavisi ile klinik semptomlar hzla dzeldi. Nefrotik sendrom ve ilerleyici grme kayb klinik olarak remisyona girdi ve kilo kayb dzeldi. Balang akcier grafisi yalnzca kronik deiiklikler gsteriyordu. Sekiz ay sonra nefes darl ve gs ars semptomlar ortaya kt ve sa da youn plevral sv saptand. leri incelemelerde plevral mezotelyoma tespit edildi.

Anahtar Kelimeler: malign mezotelyoma, minimal deiiklik hastal, nefrotik sendrom, non-arteritik iskemik optik nropati

Minimal change disease and bilateral non-arteritic ischemic optic neuropathy in a patient with pleural mesothelioma

Senyo Tagboto
Yarmouth Regional Hospital, Yarmouth, Canada; University of Health and Allied Sciences, Ho, Ghana

Malignant mesothelioma typically presents with slowly progressive dyspnea and chest pain. Extra-thoracic symptoms and paraneoplastic presentations are very rare. The association of this malignancy with glomerular disorders has been only rarely reported in the literature. The present report describes the case of a 65-year-old man with a remote occupational exposure to asbestos more than 26 years prior who presented with a months history of slowly progressive visual loss, minimal weight loss, and pedal edema. Assessments by several ophthalmologists concluded that he had developed non-arteritic ischemic optic neuropathy. Further nephrological work-up demonstrated that he had developed nephrotic syndrome due to minimal change disease, which was confirmed with a renal biopsy. His clinical symptoms rapidly improved with steroid treatment. The nephrotic syndrome went into clinical remission, his progressive visual loss improved, and there was no further weight loss. The initial chest X-ray performed when he first presented was reported as showing only chronic changes. He reported the symptoms of shortness of breath and chest pain 8 months later and was found to have a large right pleural effusion. Further investigation revealed pleural mesothelioma.

Keywords: Malignant mesothelioma, minimal change disease, nephrotic syndrome, non-arteritic ischaemic optic neuropathy

Senyo Tagboto. Minimal change disease and bilateral non-arteritic ischemic optic neuropathy in a patient with pleural mesothelioma. Respir Case Rep. 2019; 8(1): 21-25

Sorumlu Yazar: Senyo Tagboto, Canada
Makale Dili: ngilizce
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