Fluorourasil, Leucoverin ve Oxaliplatin Tedavisine Sekonder Akci�er Toksistesi: Olgu Sunumu

Tokg�z Aky�l, Fatma; Akyil, Mustafa; �en, Erdem; A�ca, Meltem; Sevim, T�lin

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Fluorourasil, Leucoverin ve Oxaliplatin Tedavisine Sekonder Akci�er Toksistesi: Olgu Sunumu [Respir Case Rep]

Respir Case Rep. 2019; 8(1): 26-30 | DOI: 10.5505/respircase.2019.43433

Fluorourasil, Leucoverin ve Oxaliplatin Tedavisine Sekonder Akci�er Toksistesi: Olgu Sunumu

Fatma Tokg�z Aky�l¹, Mustafa Akyil², Erdem �en³, Meltem A�ca⁴, T�lin Sevim⁴
¹�anakkale Devlet Hastanesi, G��s Hastal�klar�
²�anakkale Devlet Hastanesi, G��s Cerrahisi
³�anakkale Devlet Hastanesi, Onkoloji
⁴Sureyyapa�a G��s Hastal�klar� Ve G��s Cerrahisi E�itim Ve Ara�t�rma Hastanesi, G��s Hastal�klar�

G�n�m�zde, FOLFOX (5-fluorourasil, leucoverin ve oxaliplatin) ileri evre veya metastatik
gastrointestinal sistem t�m�rlerinde ilk s�rada kullan�lan kemoterap�tik rejimdir. Bu rejimin
hematolojik, gastrointestinal ve sens�rin�ral sistem ile ilgili yan etkileri bilinmesine kar��n pulmoner
toksisitesi s�n�rl� say�da olgu bildirimleri d�zeyindedir. H�zla ilerleyerek mortal seyredebilece�inden
akci�er toksisitesinin erken fark�ndal�� ve tedavisi �nemlidir. Bu yaz�da, metastatik �zofagus kanseri
nedeniyle kullan�lan FOLFOX tedavisine sekonder geli�en interstisyel akci�er hastal�� olgusu nadir
olmas� nedeniyle sunulmu�tur.

Anahtar Kelimeler: ila� toksisitesi, interstisyel akci�er hastal��, oxaliplatin

Pulmonary Toxicity Secondary to Fluorouracil, Leucoverin and Oxaliplatin Treatment: A Case Report

Fatma Tokg�z Aky�l¹, Mustafa Akyil², Erdem �en³, Meltem A�ca⁴, T�lin Sevim⁴
¹Canakkale State Hospital, Pulmonology
²Canakkale State Hospital, Thoracic Surgery
³Canakkale State Hospital, Oncology
⁴Sureyyapasa Chest Diseases And Thoracic Surgery Training And Research Hospital, Pulmonology

To date, 5-fluorourasil, leucovorin, and oxaliplatin (FOLFOX) continues to be used as a first-line treatment for advanced or metastatic gastrointestinal system tumors. Though associated hematological, gastrointestinal, and neurosensory toxicities are widely known, pulmonary toxicity has solely been described in case reports. Early diagnosis and treatment is extremely important, since the toxicity may lead to rapid deterioration and mortality. Presently described is the case of a female patient with interstitial lung disease secondary to undergoing a FOLFOX regimen for metastatic esophagus cancer.

Keywords: drug toxicity, interstitial lung disease, oxaliplatin

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Tedavi Sonras�

Sorumlu Yazar: Fatma Tokg�z Aky�l, T�rkiye
Makale Dili: T�rk�e

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